Distribution of the 23-bp polymorphism of the prion protein gene in Jersey cattles in Turkey

Background: Bovine spongiform encephalopathy (BSE) is a prion disease that always fatal in cattle and considered an important risk factor for human health. Genetic polymorphisms alter proteins may be associated with susceptibility or resistance to infectious encephalopathy. Therefore, we investigated the distribution of 23 bp indel variant protein (PRNP) gene Jersey Turkey. Methods: A total 95 unrelated (79 reproductive age 16 non-reproductive age) from private farm Izmir were included study. Genomic DNA was obtained milk reproductive-age saliva non-reproductive-age cattle. 23-bp polymorphism PRNP promoter region genotyped by polymerase chain reaction (PCR) analysis. Results: The three genotypes classified as follows: (223 bp), I/D (both 223 200 fragments), D/D (200 bp). frequencies I/I, I/D, 22 (23.16%), 48 (50.53%), 25 (26.32%). We then examined genotype allele according service period. No significant difference detected terms bp-indel groups created period (p>0.05). Conclusion: Although jersey-type Turkey did not differ period, our results benefit understanding genetic characteristics breeds.